abstract：:Environmental pollutant, Lead (Pb) is known to induce neurotoxicity in human. The central nervous system is the most vulnerable to the minute levels of Pb induced toxicity. Pb has been linked to Alzheimer's disease (AD) as a probable risk factor, as it shows epigenetic and developmental link associated with Alzheimer'...

journal_title：Chemico-biological interactions

authors： Ayyalasomayajula N,Bandaru M,Dixit PK,Ajumeera R,Chetty CS,Challa S

更新日期：2020-01-25 00:00:00

abstract：BACKGROUND:Head and neck squamous cell carcinoma (HNSCC) is one of the most common lethal tumors with a high recurrence rate and low survival rate. Therefore, an urgent need exists for novel and effective treatment strategies for HNSCC patients. METHODS:Osthole, a natural ingredient extracted from Cnidium monnieri (L....

journal_title：Chemico-biological interactions

authors： Yang J,Zhu XJ,Jin MZ,Cao ZW,Ren YY,Gu ZW

更新日期：2020-01-25 00:00:00

abstract：:Stearoyl-CoA desaturase (SCD) generates monounsaturated fatty acids (MUFAs) which contribute to cell growth, survival, differentiation, metabolic regulation and signal transduction. Overexpression of SCD is evident and implicated in metabolic diseases such as diabetes and non-alcoholic fatty liver disease. SCD also st...

journal_title：Chemico-biological interactions

authors： Kikuchi K,Tsukamoto H

更新日期：2020-01-25 00:00:00

abstract：:Gentamicin-induced nephrotoxicity has been well documented, although the causing mechanisms and preventative measures need further investigation. The current study aimed to explore the potential protective impacts of celecoxib, a selective cyclooxygenase-2 (COX-2) inhibitor, on gentamicin-induced nephrotoxicity and th...

journal_title：Chemico-biological interactions

authors： Abdelrahman RS,Abdelmageed ME

更新日期：2020-01-05 00:00:00

abstract：:Type II diabetes is recognized as a major risk factor for death due to cardiovascular complications such as coronary heart disease (CHD), but the complex interplay between these two diseases remains poorly understood. Suppression of oxidative stress, apoptosis, and inflammation of endothelial cells is a valuable treat...

journal_title：Chemico-biological interactions

authors： Zhang L,Qi X,Zhang G,Zhang Y,Tian J

更新日期：2020-01-05 00:00:00

abstract：:Cyclo (L-Leucyl-L-Prolyl) peptide/CLP is a marine natural metabolite and well recognized as an antimicrobial and antioxidant agent with limited studies on anticancer activity. The current study aims to determine the effect of CLP on migration and growth of triple negative breast cancer cell lines. The anti-growth pote...

journal_title：Chemico-biological interactions

authors： Kgk D,Kumari S,G S,Malla RR

更新日期：2020-01-05 00:00:00

abstract：:4-methylesculetin (4 ME) is a natural antioxidant coumarin with protective effects on the intestinal inflammation, in which oxidative stress plays a key role in its aetiology and pathophysiology. Based on this, we examined the antioxidant molecular mechanisms involved in the intestinal anti-inflammatory activity of th...

journal_title：Chemico-biological interactions

authors： Tanimoto A,Witaicenis A,Caruso ÍP,Piva HMR,Araujo GC,Moraes FR,Fossey MC,Cornélio ML,Souza FP,Di Stasi LC

更新日期：2020-01-05 00:00:00

abstract：:Depression is a common neuropsychiatric disorder whose pathophysiology has been associated with glutamatergic excitotoxicity. Thus, the research for new antidepressant strategies with the ability to mitigate glutamate toxicity has received growing attention. Given this background, the present study sought to investiga...

journal_title：Chemico-biological interactions

authors： Dalmagro AP,Camargo A,Severo Rodrigues AL,Zeni ALB

更新日期：2019-12-01 00:00:00

abstract：:Phenazines, naturally produced by bacteria and archaeal Methanosarcina species are nitrogen-containing tricyclic molecules with antibiotic, antitumoral, and antiparasitic activities. Phenazines are used as electron acceptors-donors in wide range of fields including environmental biosensors. In this study, the inhibito...

journal_title：Chemico-biological interactions

authors： Onder S,Biberoglu K,Tacal O

更新日期：2019-12-01 00:00:00

abstract：:Nicorandil ameliorated doxorubicin-induced nephrotoxicity; this study aimed to show and explain the mechanism of this protection. A precise method was elucidated to study the effect of nicorandil on doxorubicin-induced nephrotoxicity in rats depending on the critical inflammation pathway TLR4/MAPK P38/NFκ-B. Adult mal...

journal_title：Chemico-biological interactions

authors： Khames A,Khalaf MM,Gad AM,Abd El-Raouf OM,Kandeil MA

更新日期：2019-09-25 00:00:00

abstract：:Ursodeoxycholic acid (UDCA) is a major effective constituent of bear bile powder, which is widely used as function food in China and is documented in the Chinese pharmacopoeia as a traditional Chinese medicine. UDCA has been developed as the only accepted therapy by the US FDA for primary biliary cholangitis. Recently...

journal_title：Chemico-biological interactions

authors： Zhou D,Kong L,Jiang Y,Wang C,Ni Y,Wang Y,Zhang H,Ruan J

更新日期：2019-09-01 00:00:00

abstract：BACKGROUND:The human body is a home to thousands of microbiotas. It is defined as a community of symbiotic, commensal and pathogenic microorganisms that have existed in all exposed sites of the body, which have co-evolved with diet, lifestyle, genetic factors and immune factors. Human microbiotas have been studied for ...

journal_title：Chemico-biological interactions

authors： Chellappan DK,Sze Ning QL,Su Min SK,Bin SY,Chern PJ,Shi TP,Ee Mei SW,Yee TH,Qi OJ,Thangavelu L,Rajeshkumar S,Negi P,Chellian J,Wadhwa R,Gupta G,Collet T,Hansbro PM,Dua K

更新日期：2019-09-01 00:00:00

abstract：:Acetylcholinesterase (AChE) is an enzyme which terminates the cholinergic neurotransmission, by hydrolyzing acetylcholine at the nerve and nerve-muscle junctions. The reversible inhibition of AChE was suggested as the pre-treatment option of the intoxications caused by nerve agents. Based on our derived 3D-QSAR model ...

journal_title：Chemico-biological interactions

authors： Vitorović-Todorović MD,Worek F,Perdih A,Bauk SĐ,Vujatović TB,Cvijetić IN

更新日期：2019-08-25 00:00:00

abstract：:Formic acid is a common organic acid used in many industrial processes. There is a paucity of research on the direct toxicity of formic acid and how it might affect the cardiovascular system. This study aimed to understand the effect of formic acid on vascular tension in an animal model and the underlying mechanism. R...

journal_title：Chemico-biological interactions

authors： Zhang Q,Niu Y,Lyu W,Yu M

更新日期：2019-08-25 00:00:00

abstract：:The reactive oxygen species (ROS) induced oxidative stress is an inevitable factor for the pathogenesis of cardiovascular diseases. The edible marine algae-derived sulfated polysaccharides gained special attention as novel bioactive compounds having potential pharmacological activities. The present study evaluated in ...

journal_title：Chemico-biological interactions

authors： V S L,Rauf AA,Kurup GM

更新日期：2019-08-01 00:00:00

abstract：:Organophosphorus compounds have been widely employed to the development of warfare nerve agents and pesticides, resulting in a huge number of people intoxicated annually, being a serious problem of public health. Efforts worldwide have been done in order to design new technologies that are capable of combating or even...

journal_title：Chemico-biological interactions

authors： Pereira AF,de Castro AA,Soares FV,Soares Leal DH,da Cunha EFF,Mancini DT,Ramalho TC

更新日期：2019-08-01 00:00:00

abstract：:Chrysin belongs to the flavonoids and has been used as traditional medicine from ancient and has been reported to exhibit a wide range of pharmacological properties. The biochemical and molecular mechanisms involved in the hepato- and nephroprotective activities of chrysin were discussed in this review. Chrysin exhibi...

journal_title：Chemico-biological interactions

authors： Pingili RB,Pawar AK,Challa SR,Kodali T,Koppula S,Toleti V

更新日期：2019-08-01 00:00:00

abstract：:Within the alpha/beta hydrolase fold superfamily of proteins, the COesterase group (carboxylesterase type B, block C, cholinesterases …) diverged from the other groups through simultaneous integration of an N-terminal, first disulfide bond and a significant increase in the protein mean size. This first disulfide bond ...

journal_title：Chemico-biological interactions

authors： Chatonnet A,Brazzolotto X,Hotelier T,Lenfant N,Marchot P,Bourne Y

更新日期：2019-08-01 00:00:00

abstract：:Increasing evidence has shown that dysregulation of microRNA-621 (miR-621) is demonstrated to be associated with several cancers. However, the role of miR-621 in bladder cancer (BCa) remains unclear. Herein, we aimed to study the expression pattern, biological function, and molecular mechanism of miR-621 in BCa. First...

journal_title：Chemico-biological interactions

authors： Tian H,Wang X,Lu J,Tian W,Chen P

更新日期：2019-08-01 00:00:00

abstract：:This study is aimed to investigate whether Mabuterol (Mab) inhibits proliferation of airway smooth muscle cells (ASMCs) induced by platelet-derived growth factor BB (PDGF-BB) and how far it is related to mitochondrial fission/fusion and intracellular calcium if it comes into play. To explore the mechanism of Mab's ant...

journal_title：Chemico-biological interactions

authors： Gu Y,Yu X,Li X,Wang X,Gao X,Wang M,Wang S,Li X,Zhang Y

更新日期：2019-07-01 00:00:00

abstract：:MicroRNAs (miRNAs) have been regarded as potential modulators in varying ocular diseases, including age-related cataract (ARC). However, the roles of miR-221 in ARC progression and its underlying mechanism remain poorly understood. In this study, human lens epithelial cell line (SRA01/04) was used to investigate the p...

journal_title：Chemico-biological interactions

authors： Gong W,Li J,Wang Y,Meng J,Zheng G

更新日期：2019-06-01 00:00:00

abstract：:The inhibitory effects of antihypertensive drugs (dihydropyridine calcium channel blockers, angiotensin II receptor blockers, and angiotensin-converting enzyme inhibitors) on cytochrome P450 2J2 (CYP2J2) activity were examined. Amlodipine, azelnidipine, barnidipine, benidipine, cilnidipine, efonidipine, felodipine, ma...

journal_title：Chemico-biological interactions

authors： Ikemura N,Yamaori S,Kobayashi C,Kamijo S,Murayama N,Yamazaki H,Ohmori S

更新日期：2019-06-01 00:00:00

abstract：:In terms of drug disposal and metabolism SDR21C1 (carbonyl reductase 1; CBR1) exerts an assorted substrate spectrum among a large variety of clinically relevant substances. Additionally, this short-chain dehydrogenase/reductase is extensively expressed in most tissues of the human body, thus underpinning its role in x...

journal_title：Chemico-biological interactions

authors： Seliger JM,Martin HJ,Maser E,Hintzpeter J

更新日期：2019-05-25 00:00:00

abstract：:Mammalian steroid 5β-reductases belong to the Aldo-Keto Reductase 1D sub-family and are essential for the formation of A-ring 5β-reduced steroids. Steroid 5β-reduction is required for the biosynthesis of bile-acids and the metabolism of all steroid hormones that contain a Δ4-3-ketosteroid functionally to yield the 5β-...

journal_title：Chemico-biological interactions

authors： Chen M,Wangtrakuldee P,Zang T,Duan L,Gathercole LL,Tomlinson JW,Penning TM

更新日期：2019-05-25 00:00:00

abstract：:Ribosomal protein S15A (RPS15A) has emerged as a novel oncogene of various human cancers. However, whether RPS15A is involved in pancreatic cancer remains unclear. In this study, we aimed to investigate the potential relevance of RPS15A in pancreatic cancer and elucidate the underlying regulatory mechanism. We found t...

journal_title：Chemico-biological interactions

authors： Liang J,Liu Y,Zhang L,Tan J,Li E,Li F

更新日期：2019-05-01 00:00:00

abstract：:Exposure to lead (Pb) poses a threat to human bone health, including changes in bone mineral composition and the inhibition of skeletal growth and bone maturation. However, little is known about how Pb directly affects osteoblasts. In this work, we found that sub-toxic Pb concentrations suppressed bone nodule formatio...

journal_title：Chemico-biological interactions

authors： Sun K,Mei W,Mo S,Xin L,Lei X,Huang M,Chen Q,Han L,Zhu X

更新日期：2019-04-25 00:00:00

abstract：:Pelargonidin (PEL) is a well-known red pigment found in plants, and has been reported as having important biological activities that are potentially beneficial for human health. Here, we tested the possible use of PEL in the treatment of lipopolysaccharide (LPS)-mediated vascular inflammatory responses. The anti-infla...

journal_title：Chemico-biological interactions

authors： Lee BS,Lee C,Yang S,Park EK,Ku SK,Bae JS

更新日期：2019-04-01 00:00:00

abstract：:ALDH1L1 (cytosolic 10-formyltetrahydrofolate dehydrogenase) is the enzyme in folate metabolism commonly downregulated in human cancers. One of the mechanisms of the enzyme downregulation is methylation of the promoter of the ALDH1L1 gene. Recent studies underscored ALDH1L1 as a candidate tumor suppressor and potential...

journal_title：Chemico-biological interactions

authors： Krupenko SA,Krupenko NI

更新日期：2019-04-01 00:00:00

abstract：:Current regulatory practices for chemical carcinogens were established when scientific understanding of the molecular mechanisms of chemical carcinogenesis was in its infancy. Initial discovery that DNA mutation was the root of cancer led quickly to regulatory processes that assumed such a simple relationship could be...

journal_title：Chemico-biological interactions

authors： Clewell RA,Thompson CM,Clewell HJ 3rd

更新日期：2019-03-01 00:00:00

abstract：:Osteoporosis is accompanied by insufficient osteogenic capacity. Several lines of evidence suggested that solutions to enhance osteoblastogenesis were important strategies for osteoporotic bone defect repair. This study investigated the effect of combined treatment with vitamin K2 and PTH on bone formation in calvaria...

journal_title：Chemico-biological interactions

authors： Weng SJ,Yan DY,Gu LJ,Chen L,Xie ZJ,Wu ZY,Tang JH,Shen ZJ,Li H,Bai BL,Boodhun V,Yang L

更新日期：2019-02-25 00:00:00

abstract：:Mammary serine protease inhibitor or Maspin has been characterized as a class II tumor suppressor gene in several cancer types, among them prostate cancer (CaP). Androgen ablation is an effective therapy for CaP, but with short-term effectiveness, thus new therapeutic strategies are actively sought. The present study ...

journal_title：Chemico-biological interactions

authors： Cocchiola R,Lopreiato M,Guazzo R,de Santi MM,Eufemi M,Scandurra R,Scotto d'Abusco A

更新日期：2019-02-25 00:00:00

abstract：:Chronic pancreatitis is characterized by pancreatic fibrosis, associated with excessive activation of pancreatic stellate cells (PSCs) and increased expression of transforming growth factor-β1 (TGF-β1). Recently, our studies have shown that autophagy inhibitor could inhibit PSCs activation and reduce collagen secretio...

journal_title：Chemico-biological interactions

authors： Cui LH,Li CX,Zhuo YZ,Yang L,Cui NQ,Zhang SK

更新日期：2019-02-25 00:00:00

abstract：:Diabetes mellitus is the world's most common endocrine disease involving metabolic disorders of carbohydrate, protein and fat. This study was undertaken to investigate the anti-diabetic activity of corilagin, a member of polyphenolic tannins used against hyperglycemia and many other diseases in well-known animal model...

journal_title：Chemico-biological interactions

authors： Nandini HS,Naik PR

更新日期：2019-02-01 00:00:00

abstract：:Melatonin is a hormone produced in animals by the pineal gland and in plants under stress. Melatonin research has expanded rapidly, affecting an impressive enhancement in the understanding of its functions in plants and animals. However, far less focus has been directed to clarifying the nature of melatonin dose-respo...

journal_title：Chemico-biological interactions

authors： Agathokleous E,Kitao M,Calabrese EJ

更新日期：2019-02-01 00:00:00

abstract：:2-Hydroxy-3',5,5'-trimethoxychalcone (named DK-139) is a synthetic chalcone derivative that has anti-inflammatory, anti-tumor, and endoplasmic reticulum-mediated apoptosis activities. However, the mode of action of DK-139 on reactive oxygen species (ROS)-induced apoptosis remains unknown. In this study, we found that ...

journal_title：Chemico-biological interactions

authors： Gil HN,Jung E,Koh D,Lim Y,Lee YH,Shin SY

更新日期：2019-01-25 00:00:00

abstract：:Rutin possesses multiple pharmacological activities, including the cardioprotective effect. The present study aimed to evaluate the protective effects of rutin on hypoxia/reoxygenation (H/R)-induced myocardial injury and its underlying mechanism involved. H9c2 cells were pretreated with 50 μM rutin or combined with 1 ...

journal_title：Chemico-biological interactions

authors： Yang H,Wang C,Zhang L,Lv J,Ni H

更新日期：2019-01-05 00:00:00

abstract：:Plant-based systems continue to play an essential role in healthcare, and their use by different cultures has been extensively documented. Baccharis trimera, popularly known as carqueja, is a plant widely distributed in South America and has been traditionally used for treating several diseases particularly associated...

journal_title：Chemico-biological interactions

authors： Silveira Rabelo AC,Caldeira Costa D

更新日期：2018-12-25 00:00:00

abstract：:Recent evidences demonstrated that ingestion of several monoterpenes cause hepatic and renal damage due to impairment on mitochondrial energy production, eliciting a collapse on adenosine triphosphate (ATP) synthesis and consequently impairment on bioenergetic homeostasis. Thus, the aim of this study was to evaluate w...

journal_title：Chemico-biological interactions

authors： Baldissera MD,Souza CF,De Matos AFIM,Baldisserotto B,da Silva AS,Monteiro SG

更新日期：2018-12-25 00:00:00

abstract：:Dimethylnitrosamine (DMN) is a potent hepatotoxic, carcinogenic and mutagenic compound. It induces massive liver cell necrosis and death in experimental animals. Several drugs have been tested in the past for their protective behavior against DMN toxicity. However, it is for the first time that therapeutic interventio...

journal_title：Chemico-biological interactions

authors： Rani V,Verma Y,Rana K,Rana SVS

更新日期：2018-11-01 00:00:00

abstract：:Deoxypodophyllotoxin (DPT) is a naturally occurring flavolignan in Anthriscus sylvestris known as cow parsley or wild chervil, and has been reported to have inhibitory effects against several pathological processes including cancer, inflammation and infection. Here, we report the effects of DPT in the fatty liver indu...

journal_title：Chemico-biological interactions

authors： Kim KY,Park KI,Lee SG,Baek SY,Lee EH,Kim SC,Kim SH,Park SG,Yu SN,Oh TW,Kim JH,Kim KJ,Ahn SC,Kim YW

更新日期：2018-10-01 00:00:00